Dynamic Requirements for a Functional Protein Hinge
نویسندگان
چکیده
منابع مشابه
Mutations in the hinge of a dynamic loop broadly influence functional properties of fructose-1,6-bisphosphatase.
Loop 52-72 of porcine fructose-1,6-bisphosphatase may play a central role in the mechanism of catalysis and allosteric inhibition by AMP. The loop pivots between different conformational states about a hinge located at residues 50 and 51. The insertion of proline separately at positions 50 and 51 reduces k(cat) by up to 3-fold, with no effect on the K(m) for fructose 1,6-bisphosphate. The K(a) ...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2007
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2007.01.074